Paramount Pictures and Skydance have released the first trailer for Annihilation, the latest movie from Ex Machina and 28 Days Later director, Alex Garland. Annihilation star Natalie Portman and is based on the first instalment of the Southern Reach trilogy from novelist, Jeff Vander Meer.

Annihilation stars Natalie Portman, Jennifer Jason Leigh, Gina Rodriguez, Tessa Thompson, Tuva Novotny, and Oscar Isaac.

Watch the trailer below:

You can read the official description of the film below, which was released when Annihilation was first announced in 2014.

Area X has been cut off from the rest of the continent for decades. Nature has reclaimed the last vestiges of human civilization. The first expedition returned with reports of a pristine, Edenic landscape; all the members of the second expedition committed suicide; the third expedition died in a hail of gunfire as its members turned on one another; the members of the eleventh expedition returned as shadows of their former selves, and within months of their return, all had died of aggressive cancer.

This is the twelfth expedition.

Their group is made up of four women: an anthropologist; a surveyor; a psychologist, the de facto leader; and our narrator, a biologist. Their mission is to map the terrain and collect specimens; to record all their observations, scientific and otherwise, of their surroundings and of one another; and, above all, to avoid being contaminated by Area X itself.

They arrive expecting the unexpected, and Area X delivers—they discover a massive topographic anomaly and life forms that surpass understanding—but it’s the surprises that came across the border with them, and the secrets the expedition members are keeping from one another, that change everything.

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